Cumulase is the first and only recombinant human hyaluronidase for cumulus removal in the IVF process. Cumulase replaces bovine and ovine animal-derived hyaluronidases used to prepare oocytes for certain in vitro fertilization (IVF) procedures. Thanks to recombinant DNA technology, Cumulase has many advantages over existing slaughterhouse-derived hyaluronidase enzymes. The purity of Cumulase is up to 100-fold higher than currently used bovine preparations, allowing for lot-to-lot consistency that animal extract suppliers cannot deliver. It may also reduce, if not eliminate, the risk of damage or trauma to the oocytes, and eliminates the risk of animal pathogen contamination, providing a safer, purer, and more reliable alternative to slaughterhouse-derived enzymes.